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 | Acesso ao texto completo restrito à biblioteca da Embrapa Pantanal. Para informações adicionais entre em contato com cpap.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Pantanal. |
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Data corrente: |
17/07/2014 |
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Data da última atualização: |
19/05/2017 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
BORSATO, D. M.; PRUDENTE, A. S.; DOLL-BOSCARDIN, P. M.; BORSATO, A. V.; LUZ, C. F. P.; MAIA, B. H. L. N. S.; CABRINI, D. A.; OTUKI, M. F.; MIGUEL, M. D.; FARAGO, P. V.; MIGUEL, O. G. |
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Afiliação: |
DÉBORA M. BORSATO, UFPR; ARTHUR S. PRUDENTE, UFPR; PATRÍCIA M. DOLL BOSCARDIN, UEPG; AURELIO VINICIUS BORSATO, CPAP; CYNTHIA F. P. LUZ, INSTITUTO DE BOTÂNICA; BEATRIZ H. L. N. S. MAIA, UFPR; DANIELA A. CABRINI, UFPR; MICHEL F. OTUKI, UEPG; MARILIS D. MIGUEL, UFPR; PAULO V. FARAGO, UEPG; OBDULIO G. MIGUEL, UFPR. |
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Título: |
Topical anti-inflammatory activity of a monofloral honey of Mimosa scabrella provided by Melipona marginata during winter in southern Brazil. |
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Ano de publicação: |
2014 |
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Fonte/Imprenta: |
Journal of Medicinal Food, v. 17, n. 7, p. 817-825, 2014. |
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ISSN: |
1096-620X |
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DOI: |
10.1089/jmf.2013.0024 |
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Idioma: |
Inglês |
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Conteúdo: |
Melipona marginata is an endangered species of stingless bee from Brazil that produces honey with particular physicochemical features and a remarkable exotic flavor. To the best of our knowledge, this is the first report devoted to exploring the medicinal potential of this honey. Thus, the aim of this paper was to investigate the potential anti-inflammatory activity of honey extract from M. marginata on skin inflammation. The honey sample was classified as a monofloral honey of Mimosa scabrella. The presence of 11 phenolic compounds as kaempferol and caffeic acid was detected using the highperformance liquid chromatography-electrospray ionization-tandem mass spectrometry (HPLC-UV-ESI-MS) method. The anti-inflammatory activity was measured using a 12-O-tetradecanoylphorbol-13-acetate-induced ear edema model of inflammation in mice. The topical application of the M. marginata honey extract (1.0 mg/ear) was able to reduce ear edema with an inhibitory effect of 54 ? 5%. This extract decreased the myeloperoxidase activity in 75 ? 3%, which suggests a lower leucocyte infiltration that was confirmed by histological analysis. This extract also provided a reduction of 55 ? 14% in the production of reactive oxygen species. This anti-inflammatory activity could be due to a synergic effect of the phenolic compounds identified in the honey sample. Taken together, these results open up new possibilities for the use of M. marginata honey extract in skin disorders. |
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Palavras-Chave: |
Ear edema; HPLC-UV-ESI-MS analysis; Monofloral honey; Pollen analysis; Stingless bee. |
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Thesagro: |
Mimosa Scabrella. |
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Thesaurus Nal: |
phenolic compounds. |
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Categoria do assunto: |
-- |
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Marc: |
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100 1 $aBORSATO, D. M.
245 $aTopical anti-inflammatory activity of a monofloral honey of Mimosa scabrella provided by Melipona marginata during winter in southern Brazil.
260 $c2014
520 $aMelipona marginata is an endangered species of stingless bee from Brazil that produces honey with particular physicochemical features and a remarkable exotic flavor. To the best of our knowledge, this is the first report devoted to exploring the medicinal potential of this honey. Thus, the aim of this paper was to investigate the potential anti-inflammatory activity of honey extract from M. marginata on skin inflammation. The honey sample was classified as a monofloral honey of Mimosa scabrella. The presence of 11 phenolic compounds as kaempferol and caffeic acid was detected using the highperformance liquid chromatography-electrospray ionization-tandem mass spectrometry (HPLC-UV-ESI-MS) method. The anti-inflammatory activity was measured using a 12-O-tetradecanoylphorbol-13-acetate-induced ear edema model of inflammation in mice. The topical application of the M. marginata honey extract (1.0 mg/ear) was able to reduce ear edema with an inhibitory effect of 54 ? 5%. This extract decreased the myeloperoxidase activity in 75 ? 3%, which suggests a lower leucocyte infiltration that was confirmed by histological analysis. This extract also provided a reduction of 55 ? 14% in the production of reactive oxygen species. This anti-inflammatory activity could be due to a synergic effect of the phenolic compounds identified in the honey sample. Taken together, these results open up new possibilities for the use of M. marginata honey extract in skin disorders.
650 $aphenolic compounds
650 $aMimosa Scabrella
653 $aEar edema
653 $aHPLC-UV-ESI-MS analysis
653 $aMonofloral honey
653 $aPollen analysis
653 $aStingless bee
700 1 $aPRUDENTE, A. S.
700 1 $aDOLL-BOSCARDIN, P. M.
700 1 $aBORSATO, A. V.
700 1 $aLUZ, C. F. P.
700 1 $aMAIA, B. H. L. N. S.
700 1 $aCABRINI, D. A.
700 1 $aOTUKI, M. F.
700 1 $aMIGUEL, M. D.
700 1 $aFARAGO, P. V.
700 1 $aMIGUEL, O. G.
773 $tJournal of Medicinal Food$gv. 17, n. 7, p. 817-825, 2014.
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Embrapa Pantanal (CPAP) |
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| Registros recuperados : 260 | |
| 1. |  | FERREIRA, A. Arranjos de plantas para o cultivo de sorgo sacarino. In: SEMINÁRIO TEMÁTICO AGROINDUSTRIAL DE PRODUÇÃO DE SORGO SACARINO PARA BIOETANOL, 1. 2012, Ribeirão Preto. Anais... Sete Lagoas: Embrapa Milho e Sorgo, 2012. p. 42-47. (Embrapa Milho e Sorgo. Documentos, 145).| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Milho e Sorgo. |
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| 3. | | FERREIRA, A. da S. Doenças na cultura do sorgo. In: RECOMENDAÇÕES para o cultivo do sorgo. 2. ed. rev. atual. Sete Lagoas: EMBRAPA-CNPMS, 1982. p. 55-62. (EMBRAPA-CNPMS. Circular técnica, 1).| Biblioteca(s): Embrapa Milho e Sorgo. |
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| 5. | | FERREIRA, A. da S. Ensaio Nacional de doencas de sorgo. In: EMBRAPA. Centro de Nacional de Pesquisa de Milho e Sorgo. Relatório técnico anual do Centro Nacional de Pesquisa de Milho e Sorgo 1988-1991. Sete Lagoas, 1992. p. 127-128.| Biblioteca(s): Embrapa Milho e Sorgo. |
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| 6. | | FERREIRA, A. da S. Ensaios internacionais de doenças. In: EMBRAPA. Centro de Nacional de Pesquisa de Milho e Sorgo. Relatório técnico anual do Centro Nacional de Pesquisa de Milho e Sorgo 1988-1991. Sete Lagoas, 1992. p. 128.| Biblioteca(s): Embrapa Milho e Sorgo. |
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| 16. | | CASELA, C. R.; FERREIRA, A. S. Manejo de doenças de sorgo. In: CONGRESSO NACIONAL DE MILHO E SORGO, 27.; SIMPOSIO BRASILEIRO SOBRE A LAGARTA-DO-CARTUCHO, SPODOPTERA FRUGIPERDA, 3.; WORKSHOP SOBRE MANEJO E ETIOLOGIA DA MANCHA BRANCA DO MILHO, 2008, Londrina. Agroenergia, produção de alimentos e mudanças climáticas: desafios para milho e sorgo: trabalhos e palestras. [Londrina]: IAPAR; [Sete Lagoas]: Embrapa Milho e Sorgo, 2008. 1 CD-ROM. Palestra.| Tipo: Artigo em Anais de Congresso / Nota Técnica |
| Biblioteca(s): Embrapa Milho e Sorgo. |
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| Registros recuperados : 260 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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